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Buckner JH. Nat Rev Immunol ; 10 : — Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. Nat Genet ; 39 : — Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet ; 42 : — BMC Med Genet ; 10 : IL-2 and its high-affinity receptor: genetic control of immunoregulation and autoimmunity.

Semin Immunol ; 21 : — Detecting shared pathogenesis from the shared genetics of immune-related diseases. Nat Rev Genet ; 10 : 43— Systemic sclerosis and lupus: points in an interferon-mediated continuum. Arthritis Rheum ; 62 : — Martin J, Fonseca C. The genetics of scleroderma. Curr Rheumatol Rep ; 13 : 13— The pathogenesis of systemic sclerosis.

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Annu Rev Pathol ; 6 : — Scleroderma systemic sclerosis : classification, subsets and pathogenesis. J Rheumatol ; 15 : — Clinical significance of serum levels of soluble interleukin-2 receptor in patients with localized scleroderma. Br J Dermatol ; : — Soluble serum interleukin 2 receptors in patients with systemic sclerosis. J Rheumatol ; 23 : — IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. PLoS Genet ; 5 : e Risk alleles for multiple sclerosis identified by a genomewide study.

N Engl J Med ; : — Shared and distinct genetic variants in type 1 diabetes and celiac disease. Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity ; 3 : — Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta.

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Science ; : — PLoS One ; 4 : e Reduction of regulatory T cells in skin lesions but not in peripheral blood of patients with systemic scleroderma. Ann Rheum Dis ; 70 : — Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource. Nat Genet ; 41 : — Preliminary criteria for the classification of systemic sclerosis scleroderma. Arthritis Rheum ; 23 : — Criteria for the classification of early systemic sclerosis. J Rheumatol ; 28 : — Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies.

Nat Genet ; 38 : — PLINK: a tool set for whole-genome association and population-based linkage analyses.


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Am J Hum Genet ; 81 : — Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Statist Soc B ; 57 : — Google Scholar. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics ; 21 : — Download references.

Correspondence to F D Carmona.

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Supplementary Information accompanies the paper on Genes and Immunity website. Reprints and Permissions. Martin, J. The autoimmune disease-associated IL2RA locus is involved in the clinical manifestations of systemic sclerosis. Genes Immun 13, — Download citation. Received : 17 March Revised : 11 August Accepted : 19 September Published : 20 October Issue Date : February Genes